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. Author manuscript; available in PMC: 2014 Sep 18.
Published in final edited form as: Cochrane Database Syst Rev. 2009 Jul 8;(3):CD007076. doi: 10.1002/14651858.CD007076.pub2
Methods Randomised, double blind, parallel group, partial enriched enrolment. 1-week fixed titration (8 weeks in total)
Participants Painful postherpetic neuralgia 6 months after healing of herpes zoster skin rash and pain of at least 40/100 mm or numerical rating of at least 4/11 at baseline. Mean age 72 years, 45% female, 99% white
Interventions Pregabalin 150 mg daily, n = 81
Pregabalin 300 mg daily, n = 76
Placebo daily, n = 81
Outcomes Proportion of patients with ≥ 50% decrease in mean pain score between endpoint and baseline, and other outcomes
Notes Oxford quality score: R2, D2, W1 = 5/5
Parke-Davis Pfizer sponsored
Risk of bias
Item Authors’ judgement Description
Adequate sequence generation? Yes “computer generated code”
Allocation concealment? Unclear Not described
Blinding?
All outcomes
Yes “identical capsules”