Methods | Randomised, double blind, parallel group, partial enriched enrolment. 1-week fixed titration (8 weeks in total) | |
Participants | Painful postherpetic neuralgia 6 months after healing of herpes zoster skin rash and pain of at least 40/100 mm or numerical rating of at least 4/11 at baseline. Mean age 72 years, 45% female, 99% white | |
Interventions | Pregabalin 150 mg daily, n = 81 Pregabalin 300 mg daily, n = 76 Placebo daily, n = 81 |
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Outcomes | Proportion of patients with ≥ 50% decrease in mean pain score between endpoint and baseline, and other outcomes | |
Notes | Oxford quality score: R2, D2, W1 = 5/5 Parke-Davis Pfizer sponsored |
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Risk of bias | ||
Item | Authors’ judgement | Description |
Adequate sequence generation? | Yes | “computer generated code” |
Allocation concealment? | Unclear | Not described |
Blinding? All outcomes |
Yes | “identical capsules” |