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. Author manuscript; available in PMC: 2014 Sep 18.
Published in final edited form as: Cochrane Database Syst Rev. 2009 Jul 8;(3):CD007076. doi: 10.1002/14651858.CD007076.pub2

Comparison 2. Pregabalin 300 mg daily versus placebo.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 At least 30% pain relief 8 Risk Ratio (M-H, Fixed, 95% CI) Subtotals only
  1.1 Postherpetic neuralgia 2 369 Risk Ratio (M-H, Fixed, 95% CI) 2.05 [1.53, 2.75]
  1.2 Painful diabetic neuropathy 2 482 Risk Ratio (M-H, Fixed, 95% CI) 1.32 [1.11, 1.56]
  1.3 Fibromyalgia 4 1368 Risk Ratio (M-H, Fixed, 95% CI) 1.66 [1.41, 1.95]
2 At least 50% pain relief 12 Risk Ratio (M-H, Fixed, 95% CI) Subtotals only
  2.1 Postherpetic neuralgia 4 713 Risk Ratio (M-H, Fixed, 95% CI) 2.52 [1.86, 3.42]
  2.2 Painful diabetic neuropathy 4 823 Risk Ratio (M-H, Fixed, 95% CI) 1.50 [1.23, 1.83]
  2.3 Fibromyalgia 4 1374 Risk Ratio (M-H, Fixed, 95% CI) 1.50 [1.19, 1.89]
3 Much or very much improved 8 Risk Ratio (M-H, Fixed, 95% CI) Subtotals only
  3.1 Postherpetic neuralgia 2 348 Risk Ratio (M-H, Fixed, 95% CI) 2.16 [1.43, 3.27]
  3.2 Painful diabetic neuropathy 2 359 Risk Ratio (M-H, Fixed, 95% CI) 1.59 [1.22, 2.08]
  3.3 Fibromyalgia 4 1374 Risk Ratio (M-H, Fixed, 95% CI) 1.32 [1.13, 1.54]
4 Very much improved 4 Risk Ratio (M-H, Fixed, 95% CI) Subtotals only
  4.1 Fibromyalgia 4 1352 Risk Ratio (M-H, Fixed, 95% CI) 1.59 [1.22, 2.07]
5 Withdrawal - lack of efficacy 10 2437 Risk Ratio (M-H, Fixed, 95% CI) 0.41 [0.30, 0.57]
  5.1 Postherpetic neuralgia 4 722 Risk Ratio (M-H, Fixed, 95% CI) 0.39 [0.23, 0.67]
  5.2 Painful diabetic neuropathy 2 341 Risk Ratio (M-H, Fixed, 95% CI) 0.41 [0.16, 1.04]
  5.3 Fibromyalgia 4 1374 Risk Ratio (M-H, Fixed, 95% CI) 0.43 [0.28, 0.65]
6 Somnolence 12 2910 Risk Ratio (M-H, Fixed, 95% CI) 3.96 [3.08, 5.09]
  6.1 Postherpetic neuralgia 4 713 Risk Ratio (M-H, Fixed, 95% CI) 3.40 [2.13, 5.41]
  6.2 Painful diabetic neuropathy 4 823 Risk Ratio (M-H, Fixed, 95% CI) 4.59 [2.67, 7.87]
  6.3 Fibromyalgia 4 1374 Risk Ratio (M-H, Fixed, 95% CI) 4.02 [2.80, 5.77]
7 Dizziness 11 2910 Risk Ratio (M-H, Fixed, 95% CI) 3.39 [2.82, 4.08]
  7.1 Postherpetic neuralgia 4 713 Risk Ratio (M-H, Fixed, 95% CI) 3.24 [2.27, 4.64]
  7.2 Painful diabetic neuropathy 4 823 Risk Ratio (M-H, Fixed, 95% CI) 4.74 [3.00, 7.49]
  7.3 Fibromyalgia 4 1374 Risk Ratio (M-H, Fixed, 95% CI) 3.09 [2.42, 3.94]
8 Withdrawal - adverse event 12 2910 Risk Ratio (M-H, Fixed, 95% CI) 1.92 [1.55, 2.37]
  8.1 Postherpetic neuralgia 4 713 Risk Ratio (M-H, Fixed, 95% CI) 2.70 [1.71, 4.27]
  8.2 Painful diabetic neuropathy 4 823 Risk Ratio (M-H, Fixed, 95% CI) 2.29 [1.38, 3.80]
  8.3 Fibromyalgia 4 1374 Risk Ratio (M-H, Fixed, 95% CI) 1.57 [1.19, 2.07]