1 At least 30% pain relief |
8 |
|
Risk Ratio (M-H, Fixed, 95% CI) |
Subtotals only |
1.1 Postherpetic neuralgia |
2 |
369 |
Risk Ratio (M-H, Fixed, 95% CI) |
2.05 [1.53, 2.75] |
1.2 Painful diabetic neuropathy |
2 |
482 |
Risk Ratio (M-H, Fixed, 95% CI) |
1.32 [1.11, 1.56] |
1.3 Fibromyalgia |
4 |
1368 |
Risk Ratio (M-H, Fixed, 95% CI) |
1.66 [1.41, 1.95] |
2 At least 50% pain relief |
12 |
|
Risk Ratio (M-H, Fixed, 95% CI) |
Subtotals only |
2.1 Postherpetic neuralgia |
4 |
713 |
Risk Ratio (M-H, Fixed, 95% CI) |
2.52 [1.86, 3.42] |
2.2 Painful diabetic neuropathy |
4 |
823 |
Risk Ratio (M-H, Fixed, 95% CI) |
1.50 [1.23, 1.83] |
2.3 Fibromyalgia |
4 |
1374 |
Risk Ratio (M-H, Fixed, 95% CI) |
1.50 [1.19, 1.89] |
3 Much or very much improved |
8 |
|
Risk Ratio (M-H, Fixed, 95% CI) |
Subtotals only |
3.1 Postherpetic neuralgia |
2 |
348 |
Risk Ratio (M-H, Fixed, 95% CI) |
2.16 [1.43, 3.27] |
3.2 Painful diabetic neuropathy |
2 |
359 |
Risk Ratio (M-H, Fixed, 95% CI) |
1.59 [1.22, 2.08] |
3.3 Fibromyalgia |
4 |
1374 |
Risk Ratio (M-H, Fixed, 95% CI) |
1.32 [1.13, 1.54] |
4 Very much improved |
4 |
|
Risk Ratio (M-H, Fixed, 95% CI) |
Subtotals only |
4.1 Fibromyalgia |
4 |
1352 |
Risk Ratio (M-H, Fixed, 95% CI) |
1.59 [1.22, 2.07] |
5 Withdrawal - lack of efficacy |
10 |
2437 |
Risk Ratio (M-H, Fixed, 95% CI) |
0.41 [0.30, 0.57] |
5.1 Postherpetic neuralgia |
4 |
722 |
Risk Ratio (M-H, Fixed, 95% CI) |
0.39 [0.23, 0.67] |
5.2 Painful diabetic neuropathy |
2 |
341 |
Risk Ratio (M-H, Fixed, 95% CI) |
0.41 [0.16, 1.04] |
5.3 Fibromyalgia |
4 |
1374 |
Risk Ratio (M-H, Fixed, 95% CI) |
0.43 [0.28, 0.65] |
6 Somnolence |
12 |
2910 |
Risk Ratio (M-H, Fixed, 95% CI) |
3.96 [3.08, 5.09] |
6.1 Postherpetic neuralgia |
4 |
713 |
Risk Ratio (M-H, Fixed, 95% CI) |
3.40 [2.13, 5.41] |
6.2 Painful diabetic neuropathy |
4 |
823 |
Risk Ratio (M-H, Fixed, 95% CI) |
4.59 [2.67, 7.87] |
6.3 Fibromyalgia |
4 |
1374 |
Risk Ratio (M-H, Fixed, 95% CI) |
4.02 [2.80, 5.77] |
7 Dizziness |
11 |
2910 |
Risk Ratio (M-H, Fixed, 95% CI) |
3.39 [2.82, 4.08] |
7.1 Postherpetic neuralgia |
4 |
713 |
Risk Ratio (M-H, Fixed, 95% CI) |
3.24 [2.27, 4.64] |
7.2 Painful diabetic neuropathy |
4 |
823 |
Risk Ratio (M-H, Fixed, 95% CI) |
4.74 [3.00, 7.49] |
7.3 Fibromyalgia |
4 |
1374 |
Risk Ratio (M-H, Fixed, 95% CI) |
3.09 [2.42, 3.94] |
8 Withdrawal - adverse event |
12 |
2910 |
Risk Ratio (M-H, Fixed, 95% CI) |
1.92 [1.55, 2.37] |
8.1 Postherpetic neuralgia |
4 |
713 |
Risk Ratio (M-H, Fixed, 95% CI) |
2.70 [1.71, 4.27] |
8.2 Painful diabetic neuropathy |
4 |
823 |
Risk Ratio (M-H, Fixed, 95% CI) |
2.29 [1.38, 3.80] |
8.3 Fibromyalgia |
4 |
1374 |
Risk Ratio (M-H, Fixed, 95% CI) |
1.57 [1.19, 2.07] |