Number of | Percent with outcome | |||||
---|---|---|---|---|---|---|
Outcome - daily dose | Studies | Participants | Pregabalin | Placebo | Relative risk (95% CI) | NNH (95% CI) |
Somnolence | ||||||
150 mg | 3 | 527 | 15 | 7 | 2.2 (1.3 to 3.7) | 12 (7.3 to 34) |
300 mg | 4 | 713 | 19 | 6 | 3.0 (2.1 to 5.3) | 7.4 (5.5 to 11) |
600 mg | 4 | 732 | 25 | 6 | 4.4 (2.8 to 6.8) | 5.2 (4.1 to 7.0) |
Dizziness | ||||||
150 mg | 3 | 527 | 13 | 10 | 1.3 (0.8 to 2.1) | not calculated |
300 mg | 4 | 713 | 30 | 9 | 3.2 (2.3 to 4.6) | 4.7 (3.7 to 6.5) |
600 mg | 4 | 732 | 35 | 9 | 4.0 (2.8 to 5.7) | 3.8 (3.2 to 4.9) |
Adverse event discontinuation | ||||||
150 mg | 3 | 527 | 9 | 7 | 1.3 (0.7 to 2.3) | not calculated |
300 mg | 4 | 713 | 17 | 6 | 2.7 (1.7 to 4.3) | 9.3 (6.5 to 16) |
600 mg | 4 | 732 | 19 | 5 | 3.7 (2.3 to 6.0) | 7.1 (5.3 to 11) |