Table 2.
Associations between JAK/STAT genes and risk of breast cancer by genetic ancestry and Estrogen and Progesterone Receptor Tumor Phenotype.
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|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall | ≤28% IA Ancestry | >28–70% IA Ancestry | >70% IA Ancestry | |||||||||
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| Controls | Cases | OR2 (95% CI) | Controls | Cases | OR (95% CI) | Controls | Cases | OR (95% CI) | Controls | Cases | OR (95% CI) | |
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| STAT5B (rs6503691) | ||||||||||||
| CC | 3378 | 2897 | 1.00 | 1473 | 1383 | 1.00 | 1350 | 1115 | 1.00 | 555 | 399 | 1.00 |
| CT/TT | 779 | 672 | 0.98 (0.87, 1.10) | 374 | 359 | 1.01 (0.86, 1.19) | 331 | 275 | 1.01 (0.84, 1.21) | 74 | 38 | 0.63 (0.41, 0.97) |
| P-value (raw; adjusted) | 0.713, 1.000 | 0.906, 0.906 | 0.938, 1.000 | 0.035, 0.069 | ||||||||
| STAT6 (rs3024974) | ||||||||||||
| CC | 3435 | 2868 | 1.00 | 1507 | 1394 | 1.00 | 1384 | 1097 | 1.00 | 544 | 377 | 1.00 |
| CT/TT | 720 | 698 | 1.15 (1.02, 1.29) | 340 | 346 | 1.10 (0.93, 1.30) | 295 | 292 | 1.25 (1.04, 1.50) | 85 | 60 | 1.01 (0.70, 1.46) |
| P-value (raw; adjusted) | 0.018, 0.072 | 0.268, 1.000 | 0.017, 0.068 | 0.953, 1.000 | ||||||||
| TYK2 (rs280519) | ||||||||||||
| AA | 1499 | 1265 | 1.00 | 476 | 439 | 1.00 | 681 | 562 | 1.00 | 342 | 264 | 1.00 |
| AG/GG | 2651 | 2289 | 0.96 (0.87, 1.06) | 1371 | 1295 | 1.03 (0.89, 1.20) | 995 | 821 | 0.98 (0.84, 1.13) | 285 | 173 | 0.75 (0.58, 0.96) |
| P-value (raw; adjusted) | 0.416, 1.000 | 0.704, 1.000 | 0.766, 1.000 | 0.025, 0.093 | ||||||||
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| ER+/PR+ | ER+/PR− | ER−/PR+ | ER−/PR− | |||||||||
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| JAK2 (rs1536800) | ||||||||||||
| CC | 1798 | 764 | 1.00 | 122 | 1.00 | 26 | 1.00 | 263 | 1.00 | |||
| CT/TT | 1374 | 533 | 0.92 (0.81, 1.05) | 113 | 1.22 (0.93, 1.59) | 17 | 0.85 (0.46, 1.57) | 152 | 0.75 (0.61, 0.93) | |||
| P-value (raw; adjusted) | 0.225, 1.000 | 0.150, 0.899 | 0.595, 1.000 | 0.009, 0.053 | ||||||||
| STAT3 (rs8069645)1 | ||||||||||||
| AA | 1872 | 756 | 1.00 | 133 | 1.00 | 18 | 1.00 | 253 | 1.00 | |||
| AG | 1119 | 468 | 1.00 (0.87, 1.15) | 94 | 1.16 (0.88, 1.53) | 19 | 1.91 (0.99, 3.68) | 144 | 0.96 (0.77, 1.20) | |||
| GG | 181 | 74 | 0.94 (0.70, 1.25) | 8 | 0.58 (0.28, 1.21) | 6 | 3.79 (1.46, 9.84) | 18 | 0.74 (0.44, 1.22) | |||
| P-value (raw; adjusted) | 0.785, 0.959 | 0.831, 1.000 | 0.004, 0.010 | 0.324, 0.882 | ||||||||
| STAT3 (rs6503695) | ||||||||||||
| TT | 1662 | 672 | 1.00 | 117 | 1.00 | 17 | 1.00 | 222 | 1.00 | |||
| TC | 1256 | 519 | 0.98 (0.85, 1.12) | 106 | 1.17 (0.88, 1.55) | 19 | 1.63 (0.83, 3.19) | 164 | 0.99 (0.79, 1.23) | |||
| CC | 255 | 106 | 0.93 (0.73, 1.19) | 12 | 0.62 (0.33, 1.14) | 7 | 3.10 (1.23, 7.81) | 28 | 0.83 (0.54, 1.26) | |||
| P-value (raw; adjusted) | 0.564, 0.959 | 0.687, 1.000 | 0.016, 0.029 | 0.507, 0.882 | ||||||||
| STAT3 (rs12949918) | ||||||||||||
| TT | 1428 | 578 | 1.00 | 109 | 1.00 | 13 | 1.00 | 197 | 1.00 | |||
| TC | 1371 | 573 | 0.98 (0.85, 1.13) | 97 | 0.90 (0.67, 1.21) | 23 | 2.07 (1.03, 4.19) | 171 | 0.92 (0.73, 1.15) | |||
| CC | 372 | 147 | 0.88 (0.71, 1.10) | 29 | 0.95 (0.61, 1.47) | 7 | 2.47 (0.94, 6.47) | 46 | 0.91 (0.64, 1.29) | |||
| P-value (raw; adjusted) | 0.344, 0.959 | 0.631, 1.000 | 0.030, 0.030 | 0.454, 0.882 | ||||||||
| STAT3 (rs1026916) | ||||||||||||
| GG | 1550 | 636 | 1.00 | 119 | 1.00 | 14 | 1.00 | 215 | 1.00 | |||
| GA/AA | 1622 | 662 | 0.96 (0.84, 1.09) | 116 | 0.91 (0.69, 1.19) | 29 | 2.13 (1.11, 4.09) | 200 | 0.90 (0.73, 1.11) | |||
| P-value (raw; adjusted) | 0.522, 0.959 | 0.488, 1.000 | 0.024, 0.029 | 0.317, 0.882 | ||||||||
| STAT5A (rs7217728)1 | ||||||||||||
| TT | 1836 | 740 | 1.00 | 130 | 1.00 | 16 | 1.00 | 247 | 1.00 | |||
| TC/CC | 1335 | 557 | 0.99 (0.87, 1.13) | 105 | 1.09 (0.83, 1.43) | 27 | 2.5 (1.32, 4.72) | 168 | 0.94 (0.76, 1.17) | |||
| P-value (raw; adjusted) | 0.920, 0.920 | 0.533, 0.835 | 0.005, 0.007 | 0.600, 0.600 | ||||||||
| STAT5A (rs12601982) | ||||||||||||
| AA | 2364 | 945 | 1.00 | 174 | 1.00 | 26 | 1.00 | 320 | 1.00 | |||
| AG/GG | 806 | 353 | 1.06 (0.91, 1.22) | 61 | 1.00 (0.74, 1.36) | 17 | 2.03 (1.08, 3.80) | 95 | 0.88 (0.69, 1.12) | |||
| P-value (raw; adjusted) | 0.479, 0.750 | 0.980, 0.980 | 0.027, 0.027 | 0.294, 0.461 | ||||||||
| STAT5B (rs7218653)1 | ||||||||||||
| AA | 1849 | 745 | 1.00 | 132 | 1.00 | 15 | 1.00 | 237 | 1.00 | |||
| AG/GG | 1323 | 553 | 1.00 (0.87, 1.14) | 103 | 1.07 (0.81, 1.40) | 28 | 2.85 (1.49, 5.43) | 178 | 1.07 (0.86, 1.32) | |||
| P-value (raw; adjusted) | 0.946, 0.958 | 0.631, 0.631 | 0.002, 0.003 | 0.541, 0.541 | ||||||||
1
p values for difference by ER/PR group after adjustment for multiple comparisons were 0.07, 0.05, and 0.04 respectively
2
Odds ratios (OR) and 95% confidence Intervals (CI) adjusted for age, study center, BMI during referent year, parity, and genetic ancestry. Risk estimates are shown in the table if one or more of the adjusted p values for multiple comparisons is <0.15.