Table 3.

Reaction Scope with Respect to Alkynes ^[a]

Entry	R1, R2	Product	Yield, %
1	CH2OH CH2OH		95
2	Me Me		96
3	H Ph		95
4	H tBu		73
5[b]	Ph Me		95
6[c]	CO2Et H		82
7	TIPS H		64
8[d]	cyclopropyl H		84
9[e]	CH2 NPhth H		93

^[a]Amide 0.5 mmol, CF₃CH₂OH 5 mL, alkyne 1.2 equiv, air. Yields are isolated yields. Please see Supporting information for details.

^[b]Isolated as 14/1 isomer mixture.

^[c]Minor isomer (13%) also isolated.

^[d]Isolated as 13/1 isomer mixture.

^[e]Isolated as 7/1 isomer mixture, reaction time: 18 h.