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. Author manuscript; available in PMC: 2015 Mar 15.
Published in final edited form as: Nat Commun. 2014 Sep 15;5:4910. doi: 10.1038/ncomms5910

Figure 5. Iron acquisition/utilization pathways directly regulated by Fur and regulatory network motif.

Figure 5

(a) The iron acquisition (enterobactin biosynthesis and iron/enterobatin transport), iron utilization (iron storage and iron/FeS cofactors), and FeS assembly pathways are represented. The genes regulated by HR and HA are depicted by red and blue characters, respectively. The genes regulated by RyhB-mediated mRNA degradation are depicted by green characters with black boxes. 2,3-DHBA, 2,3-dihydroxybenzoic acid; IM, inner membrane; OM, outer membrane. (b) Schematic diagram for the Fur regulatory motif reconstruction for iron metabolism. Shaded grey boxes indicate motif loops utilized by E. coli K-12 MG1655 for iron metabolism (negative/negative feedback loop motifs achieved by HR/HA modes of regulation).