Table 4.

Multivariable Cox regression models predicting disease recurrence (any recurrence and bladder-only recurrence) in patients treated with radical nephroureterectomy for upper tract urothelial carcinoma

	Any recurrence			Bladder-only recurrence
	Hazard ratio	95% CI	p value	Hazard ratio	95% CI	p value
Age, per 10 yr	0.87	0.72–1.05	0.15	0.84	0.68–1.04	0.11
ASA
<2	Reference	Reference		Reference	Reference
≥2	1.03	0.67–1.57	0.9	0.86	0.53–1.41	0.6
Pathologic stage
≤pT1	Reference	Reference	0.002	Reference	Reference	0.6
pT2	1.45	0.82–2.56		1.39	0.75–2.57
≥pT3	2.31	1.44–3.70		1.06	0.58–1.93
Pathologic grade
Low	Reference	Reference		Reference	Reference
High	1.39	0.74–2.62	0.3	1.27	0.67–2.42	0.5
Nodal status
Not done	Reference	Reference	0.3	Reference	Reference	0.04
Negative	0.66	0.40–1.10		0.65	0.37–1.14
Positive	0.80	0.40–1.63		0.25	0.08–0.74
Pathologic CIS
No	Reference	Reference		Reference	Reference
Yes	1.00	0.64–1.57	0.99	0.93	0.55–1.57	0.8
Previous bladder cancer
No	Reference	Reference		Reference	Reference
Yes	1.04	0.68–1.58	0.9	1.18	0.72–1.91	0.5
Surgical approach
ORN	Reference	Reference		Reference	Reference
LRN	0.88	0.57–1.38	0.6	0.78	0.46–1.34	0.4

ASA = American Society of Anesthesiologists; CI= confidence interval; CIS = carcinoma in situ; LRN = laparoscopic radical nephroureterectomy; ORN = open radical nephroureterectomy.