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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: Br J Haematol. 2014 Jul 8;167(1):110–120. doi: 10.1111/bjh.13005

Figure 2. 2F9 induces a profound thrombocytopenia in vivo.

Figure 2

Dogs received a median cumulative dose of 63 μg/kg 2F9 intravenously. Platelet counts were determined at the indicated times. Time zero occurred when platelet count first fell within the target platelet nadir (5-30 × 109/l), a maximum of 2 h after the last 2F9 dose, or was defined as 1 h after control antibody administration. Injection of the isotype control antibody (αYFA) had no significant effect on the platelet count. Results are shown as median and range for 5 2F9-treated dogs and 3 control dogs.