Table 1.
Hormone score group | |||
---|---|---|---|
Score 0–2 (n = 203) | Score 3–5 (n = 325) | Score 6–8 (n = 210) | |
Means (SD)a | |||
Age at blood draw, yearsb | 61.4 (4.5) | 61.5 (4.5) | 61.6 (5.2) |
Time since menopause, years | 11.6 (6.1) | 11.7 (5.7) | 11.7 (6.2) |
Age at menarche, years | 12.7 (1.5) | 12.7 (1.5) | 12.7 (1.4) |
Duration of HT use, yearsc | 4.4 (6.0) | 3.6 (4.1) | 3.5 (4.0) |
Age at first birth, years | 25.4 (3.1) | 25.7 (3.7) | 25.8 (3.3) |
Body mass index, kg/m2 | 24.4 (3.7) | 26.0 (4.7) | 28.4 (4.9) |
Body mass index at age 18, kg/m2 | 21.6 (2.8) | 21.5 (2.8) | 21.8 (3.1) |
Weight change since age 18, kg | 8.0 (9.5) | 12.4 (12.3) | 17.9 (11.9) |
Waist circumference, inches | 31.0 (3.9) | 31.9 (4.4) | 34.5 (4.3) |
Hip circumference, inches | 39.2 (4.3) | 40.2 (3.8) | 42.1 (5.1) |
Waist-to-hip ratio | 0.8 (0.2) | 0.8 (0.1) | 0.8 (0.2) |
Alcohol consumption, g/day | 4.3 (8.1) | 5.0 (9.0) | 6.6 (12.9) |
Physical activity, MET-hrs/week | 20.1 (17.8) | 18.3 (18.8) | 17.2 (17.4) |
Pack-years of smoking | 26.3 (18.9) | 26.4 (19.2) | 25.9 (22.2) |
Number of children | 3.8 (1.9) | 3.5 (1.6) | 3.5 (1.9) |
Percentages | |||
Ever parity | 92 | 94 | 94 |
Ever breastfeed | 63 | 73 | 63 |
Past HT use | 37 | 36 | 32 |
Past oral contraceptive use | 26 | 33 | 27 |
History of benign breast disease | 27 | 32 | 25 |
Family history of breast cancer | 17 | 15 | 12 |
History of bilateral oophorectomy | 10 | 15 | 12 |
History of hysterectomy | 30 | 26 | 26 |
Ever smoker | 51 | 56 | 50 |
Hormone score created as the number of hormones above (or below for SHBG) the age-adjusted geometric mean level for each hormone and includes estradiol, estrone, estrone sulfate, testosterone, androsteinedione, DHEAS, prolactin, and SHBG
aValues are means (SD) or percentages and are standardized to the age distribution of the study population
bValue is not age adjusted
cAmong past hormone therapy (HT) users