Table 2.

Association between anthropometric factors and the overall, estrogen and androgen hormone scores represented as unit change in the hormone score among 738 postmenopausal women

Anthropometric factors		N	Change in overall hormone scorea (95 % CI)	Change in estrogen hormone scoreb (95 % CI)	Change in androgen hormone scorec (95 % CI)
Body mass index (kg/m2)	<22	133	Ref.	Ref.	Ref.
	22 to <25	210	0.66**	0.45**	0.12
	25 to <30	253	1.25**	0.89**	0.03
	≥30	142	2.30**	1.57**	0.21
	Per 5 kg/m2	738	0.79	0.55	0.04
			(0.63, 0.95)**	(0.47, 0.64)**	(−0.04, 0.13)
Body Mass Index at age 18 (kg/m2) d,e	<20	188	Ref.	Ref.	Ref.
	20 to <22	267	0.42*	0.25*	0.03
	22 to <25	174	0.22	0.23*	−0.09
	≥25	76	0.84**	0.65**	0.02
	Per 5 kg/m2	705	0.49	0.40	0.00
			(0.22, 0.76)**	(0.26, 0.55)**	(−0.15, 0.15)
Weight change since age 18 (kg) e,f	<5	185	Ref.	Ref.	Ref.
	5 to <10	114	0.49*	0.25	0.02
	10 to <20	233	1.22**	0.72**	0.16
	≥20	173	2.17**	1.40**	0.19
	Per 5 kg	705	0.33	0.23	0.02
			(0.26, 0.40)**	(0.19, 0.26)**	(−0.02, 0.06)
Waist-to-hip ratioe	<0.75	129	Ref.	Ref.	Ref.
	0.75 to <0.80	163	0.57*	0.21	0.11
	0.80 to <0.84	101	0.82**	0.29	0.18
	≥0.84	132	1.13**	0.56**	0.19
	Per 0.1 units	525	0.10	0.08	0.00
			(−0.04, 0.24)	(0.00, 0.16)*	(−0.07, 0.07)
Hip circumference (inches)e	<38	128	Ref.	Ref.	Ref.
	38 to <40	109	0.43	0.29	−0.01
	40 to <43	165	0.98**	0.77**	0.03
	≥43	124	1.44**	1.02**	0.12
	Per 1 in.	526	0.12	0.08	0.02
			(0.08, 0.17)**	(0.06, 0.11)**	(0.00, 0.04)
Waist circumference (inches)e	<29	120	Ref.	Ref.	Ref.
	29 to <32	135	0.70**	0.27	0.20
	32 to <35	131	0.75**	0.45**	−0.02
	≥35	143	2.00**	1.18**	0.38**
	Per 1 in.	529	0.15	0.10	0.02
			(0.11, 0.19)**	(0.07, 0.12)**	(0.00, 0.05)*

Categorical variables adjusted for age at blood draw (cont.), time of blood draw (midnight to 8 am, 8 am to noon, noon to midnight), fasting status (yes, no), alcohol consumption (none, >0 to <5, 5 to <10, 10- < 15, 15 to <30, ≥30 g/day), physical activity (>6, 6 to <12, 12 to <24, ≥24) and smoking status (never, current, past) unless otherwise noted

Continuous variables adjusted for age at blood draw (per year), time of blood draw (midnight to 8 am, 8 am to noon, noon to midnight), fasting status (yes, no), alcohol consumption (g/day), physical activity (MET-hrs/week) and smoking status (never, current, past) unless otherwise noted

*p < 0.05; **p < 0.01

^aIncludes estradiol, estrone, estrone sulfate, androstenedione, testosterone, DHEAS, prolactin and SHBG

^bIncludes estradiol, estrone and estrone sulfate

^cIncludes androstenedione, testosterone and DHEAS

^dAdditionally adjusted for weight change since age 18

^eCategories do not add up to total (N = 738) due to missing data

^fAdditionally adjusted for BMI at age 18