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. Author manuscript; available in PMC: 2015 Sep 15.
Published in final edited form as: Cancer Res. 2014 Jul 24;74(18):4996–5007. doi: 10.1158/0008-5472.CAN-13-1807

Figure 5. Inhibition of mouse Tgfβr2 promotes a pro-inflammatory immune cell phenotype.

Figure 5

A-D, The level of F4/80 (A and B), MCP-1 (C), and MMR (D) expressing macrophages in Capan-1 and MiaPaCa-2 xenografts was determined by immunohistochemistry. The effect of 2G8 on the level of MDSC (E) and NK cells (F) in Capan-1 and MiaPaCa-2 xenografts was also evaluated by immunohistochemistry with example images shown in panel G. Graphs represent 5 animals/group with 5/pictures per animal. Results are expressed as mean+/−SEM. ***, p<0.001; #, p<0.0001 vs. control.