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. Author manuscript; available in PMC: 2015 Sep 15.
Published in final edited form as: Cancer Res. 2014 Jul 24;74(18):4996–5007. doi: 10.1158/0008-5472.CAN-13-1807

Figure 7. Inhibition of stromal Tgfβr2 promotes an epithelial phenotype in xenograft models of pancreatic cancer.

Figure 7

A-C, The expression and localization of β-catenin in Capan-1 and MiaPaCa-2 xenografts treated with control or 2G8 was determined by immunohistochemistry (scale bar, 50 µm). Localization of β-catenin to the nucleus (B) or membrane (C) was quantified. D and E, The effect of 2G8 on the expression of E-cadherin (ECAD, D) and Zeb1 (E) was also determined by immunohistochemistry. Graphs represent 5–6 animals/group with 5/pictures per animal. Results are expressed as mean+/−SEM. #, p<0.0001 vs. control.