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. 2014 Sep 17;9(9):e106867. doi: 10.1371/journal.pone.0106867

Figure 9. GDNF-transfected macrophages significantly improved motor functions in PD mouse model.

Figure 9

6-OHDA-intoxicated BALB/c mice were i.v. injected with GDNF-transfected macrophages (white bars), or PBS (black bars) 48 hours after the intoxication. A control group (grey bars) was i.c. injected with PBS, and then 48 hours later i.v. injected with PBS. Apomorphine (A) and rotarod (B) tests demonstrated statistically significant improvements in motor functions upon treatment with GDNF-carrying macrophages. Values are means ±SEM (N = 12), and p<0.05 compared with 6-ODHA-intoxicated mice.