Table 1. Effect of GDNF-transfected macrophages on inflammation and neurodegeneration in mice with PD modela.
| Treatment | CD11b+ (cells per mm2) | Total N of neurons b ×103 | ||
| PBS | 6-OHDA | PBS | 6-OHDA | |
| PBS | 10.1±1.2 | 90.0±11 (**)c | 5.9±1.4 | 2.15±0.3 (**) |
| GDNF-transfected macrophages | n/a | 63.5±5.2 (*) | n/a | 3.3±0.6 (*, #) |
| Empty-transfected macrophages | 9.8±1.0 | 87.0±11.1 | 5.7±1.5 | 2.5±0.7 |
a
BALB/c mice were i.c. injected with 6-OHDA. Forty eight hours later, the animals were i.v. injected with various macrophage-based formulations or PBS. A control group was i.c. injected with PBS, and then 48 hours later i.v. injected with PBS.
b
Total number of neurons was calculated in ipsilateral hemisphere.
c
Statistical significance is shown by asterisk: p<0.05 (*), and p<0.005 (**) compared to mice with i.c. PBS injections followed by i.v. PBS injections (healthy controls); or p<0.05 (#), compared to mice with i.c. 6-OHDA injections followed by i.v. PBS injections (PD controls). Errors are mean ±SEM, N = 7.