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. Author manuscript; available in PMC: 2015 Sep 15.
Published in final edited form as: Cancer Res. 2014 Jul 24;74(18):5195–5205. doi: 10.1158/0008-5472.CAN-14-0697

Figure 3. Combined therapy with Ad5Δ24 and GD2.CAR-T cells has superior anti-NB effect in vivo.

Figure 3

(A) NSG mice were injected s.c. on the right flank with CHLA-255 cells and inoculated i.t. by day 10 – 14 with either PBS or Ad5Δ24 (106 – 109 vp) followed by i.v. infusion of either control or GD2.CAR-T cells (107 cells) 4 days later. Tumor growth was assessed by caliper measurement. Data represent mean ± SEM. *P < 0.05 by Mixed-model ANOVA. †mice euthanized. (B) and (C) Bioluminescence of GD2.CAR-T cells labeled with FFluc. Data represent mean ± SEM. ** P < 0.01 by Student’s t test. (D) In vitro migration of GD2.CAR-T cells toward the supernatant collected from control or Ad5Δ24-infected NB cells (CHLA-255, IMR-32 and SKNLP). Data represent mean ± SEM from 3 different T-cell preparations.