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. Author manuscript; available in PMC: 2014 Oct 18.
Published in final edited form as: Nanomedicine (Lond). 2014 Mar 17;9(12):1807–1820. doi: 10.2217/nnm.14.44

Figure 3. Changes of cardiac damage markers.

Figure 3

Blood specimens were collected after a single injection of different drugs with the DNR dose at 15 mg/kg body weight. (A) CK-MB isoenzyme levels in plasma. (B) Troponin levels in plasma. The CK-MB isoenzyme (A) and troponin (B) levels were significantly higher after injection of free DNR compared with the control or NTM–DNR and CTM–DNR treatment. (C) Caspase 3/7 induction in cardiac tissues. The heart tissues from mice 5 days after treatment with DNR and CTM–DNR were homogenized, lysed and then the activity of caspase 3/7 was measured. Compared with controlled mice, there was a dose-dependent induction of the caspase 3/7 activity in heart tissues in the mice treated with free DNR, while no significant induction was observed in the mice treated with CTM–DNR at the same dose range.

CK-MB: Creatine kinase MB; CTM: CLL1-targeting micelles; DNR: Daunorubicin; NTM: Nontargeting micelles–daunorubicin; PBS: Phosphate-buffered saline.