Table 3. Association of Clinical and Pathologic Characteristics with Molecular Abnormalities (combined AAM and CaM cohorts).

	ERG rearrangement			PTEN deletion			SPINK1 overexpression			SPOP mutation
	Positive	Negative	P-value	Deleted	Wild type	P-value	Positive	Negative	P-value	Mutated	Wild type	P-value
Age at Surgery (Mean ± SD)	59.9 ± 7.0	60.7 ± 7.6	0.298	64.6 ± 7.4	59.5 ± 7.3	0.001	57.6 ± 8.2	60.9 ± 7.1	0.067	60.8 ± 7.2	60.3 ± 7.4	0.812
BMI (Mean ± SD)	26.9 ± 3.2	27.0 ± 4.8	0.622	26.4 ± 2.3	27.1 ± 4.6	0.628	26.0 ± 3.3	27.1 ± 4.5	0.190	27.0 ± 4.7	26.5 ± 3.8	0.899
Gleason Score [no./total (%)]			0.285			<0.001			0.163			0.305
6	13/37 (35)	24/37 (65)		1/35 (3)	34/35 (97)		9/36 (25)	27/36 (75)		0/29 (0)	29/29 (100)
7(3+4)	48/120 (40)	72/120 (60)		12/109 (11)	97/109 (89)		20/118 (17)	98/118 (83)		7/96 (7)	89/96 (93)
7(4+3)	9/39 (23)	30/39 (77)		5/35 (14)	30/35 (66)		4/39 (10)	35/39 (90)		4/34 (12)	30/34 (88)
8 and 9	7/22 (32)	15/22 (68)		8/18 (44)	10/18 (56)		1/22 (5)	21/22 (95)		1/19 (5)	18/19 (95)
Pathological Stage [no./total (%)]			0.139			0.003			1.000			0.259
T2	59/165 (35.8)	106/165 (64.2)		13/149 (8.7)	136/149 (91.3)		26/162 (16.0)	136/162 (84.0)		11/123 (8.9)	112/123 (91.1)
T3a	16/38 (42.1)	22/38 (57.9)		8/33 (24.2)	25/33 (75.8)		6/38 (15.8)	32/38 (84.2)		0/28 (0)	28/28 (100)
T3b	2/15 (13.3)	13/15 (86.7)		5/15 (33.3)	10/15 (66.7)		2/15 (13.3)	13/15 (86.7)		1/14 (7.1)	13/14 (92.9)
Margin Positivity [no./total (%)]	8/218 (3.7)	23/218 (10.5)	0.311	2/197 (1.0)	25/197 (12.7)	0.541	4/215 (1.9)	27/215 (12.6)	0.793	1/166 (0.6)	26/166 (15.7)	0.440
Biochemical Recurrence [no./total (%)]	7/191 (3.6)	19/191 (9.9)	0.383	7/171 (4.0)	16/171 (9.3)	0.024	5/188 (2.6)	21/188 (11.1)	0.562	2/141 (1.4)	21/141 (14.9)	0.743