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. 2014 Sep 3;5:4741. doi: 10.1038/ncomms5741

Figure 7. Modulated expression of select genes associated with regulatory T-cell phenotype during escalating dose immunotherapy.

Figure 7

Tg4 Rag-1−/− mice were EDI-treated s.c. with MBP Ac1-9[4Y]. CD4+ T-cell transcriptome analysis was undertaken at the indicated treatment stages (n=3 per time point, RNA pooled) and transcripts were grouped by two-phase SOM clustering (see Fig. 6). Heatmaps are used to illustrate the fold changes in mRNA expression of individual genes during EDI. The cluster from which individual genes are derived (illustrated in Fig. 6b) is indicated by a colour identifier. Genes that were not included in clustering analysis (did not demonstrate a two-fold or greater change at ≥;4 treatment points, compared with the PBS-treated control) are indicated by a hyphen.