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Compound 5c signaling. Oocytes were treated with DMSO (vehicle) or compound 5c and harvested when 50% of the compound 5c oocytes completed GVBD. Compound 5c treated oocytes were segregated into those that had not (−) or had (+) completed GVBD. 5c triggered progesterone-independent activation of MAPK and MPF (visualized by dephosphorylation of cdc2). MAPK activation preceded GVBD, while cdc2 activation occurred at GVBD.
