Table 3.

Cytokine Levels and Leukocyte Count Fold Change Following Thermal Ablation

	IL-1a	IL-2	IL-6	IL-10	TNFa	WBC
Primary Diagnosis
Melanoma (n=2)	1.0 ± 0.0	1.0 ± 0.0	92+126	1.0 ± 0.0	1.0 ± 0.0	1.1 ± 0.2
Kidney (n=1)	1.0	1.0	26.0	15.3	1.0	1.9
Liver (n=4)	1.6 ± 0.9	1.4 ± 0.6	8.1 ± 7.0	1.7 ± 0.5	1.0 ± 0.9	1.5 ± 0.5
Lung (n=3)	0.8 ± 0.3	0.8 ± 0.3	5.6 ± 6.0	1.0 ± 0.1	0.9 ± 0.2	1.1 ±0.3
Sarcoma (n=8)	1.1 ± 0.2	0.9 ± 0.2	3.1 ± 2.9	0.9 ± 0.1	1.0 ± 0.0	1.2 ± 0.4†
Colorectal (n=12)	1.0 ± 0.7	1.0 ± 0.8	2.5 ± 2.0	1.9 ± 2.3	1.0 ± 0.0	1.3 ± 0.4*
Head and Neck (n=2)	0.8 ± 0.08	0.8 ± 0.07	1.2 ± 0.4	1.7 ± 1.0	1.0 ± 0.0	1.4 ±0.5
Gynecologic (n=1)	1.0	0.8	0.8	1.0	1.0	0.89
Target Tumor: Primary or Met
Metastasis (n=23)	1.0 ± 0.1	0.9 ± 0.1	10 ± 37	1.5 ± 1.7	1.0 ± 0.6	1.2 ± 0.3**
Primary (n=10)	1.2 ± 0.6	1.1 ± 0.4	8.6 ± 8.2	1.0 ± 0.1	1.0 ± 0.6	1.4 ± 0.5
Ablation Site
Bone (n=2)	1.0 ± 0.0	1.0 ± 0.0	91 ± 128	1.0 ± 0.0	1.0 ±0.0	1.2 ± 0.05
Kidney (n=1)	1.0	1.0	26.1	15.3	1.0	1.9
Soft Tissue (n=2)	1.0 ± 0.0	1.0 ± 0.0	6.0 ± 5.8	0.9 ± 0.1	1.0 ± 0.0	1.2 ± 0.7
Liver (n=15)	1.2 ± 0.5	1.1 ± 0.3	4.3 ± 4.3	1.9 ± 2.1	1.0 ± 0.9	1.3 ± 0.4§
Lung	0.9 ± 0.1	0.9 ± 0.2	2.6 ± 3.1	1.1 ± 0.3	1.0 ± 0.0	1.2 ± 0.4‖
Ablation Type
Cryoablation (n=4)	1.0 ± 0.0	1.0 ± 0.0	54 ± 85	4.6 ± 7.2	1.0 ± 0.0	1.5 ± 0.4
Radiofrequency (n=16)	1.1 ± 0.5	1.0 ± 0.4	3.6 ± 4.2	1.7 ± 2.0	1.0 ± 0.8	1.4 ± 0.4‡
Microwave (n=12)	1.0 ± 0.2	1.0 ± 0.1	3.4 ± 3.4	1.2 ± 0.4	1.0 ± 0.0	1.1 ± 0.3*
Laser (n=1)	0.8	0.8	1.5	2.4	1.0	1.0
Ablation Size
<10 cm2 (n=13)	1.1 ± 0.5	0.9 ± 0.4	2.5 ± 2.6	1.1 ± 0.4	1.0 ± 0.1	1.2 ± 1.2††
10–20 cm2 (n=10)	1.0 ± 0.0	1.0 ± 0.03	24.0 ± 56	2.7 ± 4.5	1.0 ± 0.0	1.2 ± 0.4‡‡
20–30 cm2 (n=9)	1.1 ± 0.3	1.0 ± 0.1	4.9 ± 5.3	2.1 ± 2.6	1.0 ± 0.1	1.4 ± 0.4
>30 cm2 (n=1)	1.0	1.0	0.6	1.0	1.0	1.8

Note.- Values presented at mean ± standard deviation of fold change. Levels were measured post procedure (<48 hours, N=33).

^*n=10.

^†n=7.

^‡n=15.

^§n=14.

^‖n=11.

^**n=20.

^††=12.

^‡‡n=8.