Skip to main content
. Author manuscript; available in PMC: 2014 Sep 18.
Published in final edited form as: Nat Rev Drug Discov. 2013 Dec 13;13(1):63–79. doi: 10.1038/nrd4161

Figure 3. Hippo mutant phenotypes in flies and mice.

Figure 3

Figure 3

Figure 3

Figure 3

Figure 3

Figure 3

Scanning electron micrographs of (A) a wild-type fly and (B) a fly with patches (clones) of cells homozygous mutant for the hippo kinase. The hippo mutant tissues exhibit overgrowth of the adult cuticle. (C) A mouse liver at two months of age from a wild-type animal and (D) a liver at two months of age from a mouse mutant in which the two hippo homologs Mst1 and Mst2 have been conditionally deleted in the developing liver. (E) Normal mouse liver at 6 months and (F) a Mst1/2 double mutant liver at 6 months which is not only overgrown but also developed foci of hepatocellular carcinoma (HCC).