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Premature termination codon in Skint1 in FVBTac. (a) Genomic DNA sequence of Skint1 codons 322–326 from B6, FVBJax and FVBTac mice reveals a premature termination mutation in FVBTac (asterisk). (b) Schematic representation of the inferred protein structure of wild-type Skint1. Location of the FVBTac E324X mutation is indicated by ‘X’ and an arrow. The structure is inferred from domain predictions for Skint1 and its paralogs.
