Table 1. Transcription in wild-type C57BL/6 and CD27-deficient γδ T lymphocytes.
Expression of genes linked to T cell biology, presented as expression in wild-type cells relative to expression in CD27-deficient γδ T cells (‘fold’ change). Gene ID, identification number in the National Center for Biotechnology Information database. Full cDNA microarray data, ArrayExpress accession number E-NCMF-23. P=0.00003 (threshold for microarray data analysis). Data are representative of two independent experiments.
| Gene ID | Symbol | Description | Function | Expression |
|---|---|---|---|---|
| 21940 | Tnfrsf7 | CD27 (TNF-RSF7) | Activation | 21.11 |
| 17000 | Ltbr | Lymphotoxin-β receptor (TNF-RSF3) | Cytokine receptor | 9.00 |
| 12477 | Ctla4 | CTLA-4 coreceptor | Activation | 7.01 |
| 12916 | Crem | CREM/ICER | Transcription | 5.10 |
| 18227 | Nr4a2 | Nuclear orphan receptor | Transcription | 4.66 |
| 19735 | Rgs2 | Regulator of G protein signaling | Signaling | 4.17 |
| 50778 | Rgs1 | Regulator of G protein signaling | Signaling | 3.86 |
| 21943 | Tnfsf11 | RANK ligand (TNF-SF11) | Cytokine | 3.66 |
| 12487 | Cd28 | CD28 coreceptor | Activation | 3.36 |
| 19734 | Rgs16 | Regulator of G protein signaling | Signaling | 3.25 |
| 16364 | Irf4 | Interferon-regulatory factor | Transcription | 2.30 |
| 16478 | Jund1 | JunD | Transcription | 2.20 |
| 16172 | Il17ra | IL-17 receptor α-chain | Cytokine receptor | 0.14 |