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. Author manuscript; available in PMC: 2014 Sep 19.
Published in final edited form as: Neuroreport. 2003 Jan 20;14(1):43–46. doi: 10.1097/01.wnr.0000050303.92401.9e

Fig. 1.

Fig. 1

Progesterone withdrawal effects on peak GABA-gated current: increased agonist effects of gaboxadol and potentiation by pentobarbital. (a) Maximum currents gated by gaboxadol and GABA. In acutely isolated CA1pyramidal cells, the maximum GABAA-R current gated by gaboxadol (10 mM) was significantly increased (*p < 0.05, n control =15, n PWD =15) following progesterone withdrawal (PWD, dark bars) relative to control (shaded bars). In contrast, the maximum current gated by GABA (10 mM, n control =15, n PWD =15) was unaffected by PWD. (B) Potentiation of peak GABA-gated current by the GABAA-R modulator pentobarbital (PTB). PTB (100 μM, GABA EC20=10 μM) modulation of GABA-gated current was significantly (*p < 0.01) greater in hippocampal cells isolated from PWD rats (dark bar, n =20) than controls (open bar, n =20).

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