Fig. 2.

Progesterone withdrawal increases the anxiolytic effects of gaboxadol and pentobarbital in the elevated plus maze. Anxiety Measures in the EPM – The anxiolytic effect of gaboxadol (1.25 mg/kg) was increased during PWD (dark bars) relative to controls (hatched bars). For this and the following graphs, sample size is indicated at the base of the bars in panel D and significant effects relative to controls injected with the same substance at p < 0.005 is indicated by *. (a) Both gaboxadol and PTB significantly increased time spent in the open arm following PWD relative to control animals with similar injections. (b) Gaboxadol significantly increased the number of open arm entries only during PWD. (c) This figure depicts the number of open arm entries (OAE) corrected for locomotor activity by presenting these data as a percentage of grid crosses (% OAE). Gaboxadol injected animals have a higher % OAE only during PWD. (d) Locomotor activity is illustrated as total number of grid crosses in a 10 min test period. There were no significant effects of locomotor activity across treatment conditions.