TABLE I.
Average DPOAE adaptation/MEM-R values measured in alert rabbits predicted susceptibility to OBN-induced decrements in DPOAE levels in both the delayed-monaurally and binaurally tested conditions. Right most column displays average DPOAE loss determined over the same frequency region that DPOAE adaptation/MEM-R was calculated (see text). Last three rows show significance values when DPOAE adaptation/MEM-R values are compared with DPOAE losses, for each animal (right and left ears averaged). Note in deeply anesthetized animals, DPOAE adaptation/MEM-R values were not predictive of the OBN-induced reductions in DPOAE levels.
| Rabbit Ear/Statistics for avg. DPOAE adaptation index/MEM-R (dB) vs DPOAE Loss @ 65 dB SPL | Monaural Awake | Binaural Awake | Monaural Anesthetized | Binaural Anesthetized | Avg. OBN- Induced DPOAE Loss in dB for | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary Level (dB SPL) | 55 | 65 | 75 | 55 | 65 | 75 | 55 | 65 | 75 | 55 | 65 | 75 | 65-dB SPL primaries |
| 42L | 2.0/0.2 | 2.4/0.5 | 3.5/1.4 | 3.0/0.4 | 4.4/1.9 | 12.8/3.4 | 3.9/1.2 | 2.8/1.2 | 3.6/1.1 | 7.7/2.3 | 6.3/2.4 | 7.5/2.3 | 23.3 |
| 42R | 1.9/1.9 | 2.3/2.1 | 3.5/3.0 | 3.2/3.2 | 5.6/4.6 | 11.6/5.9 | 0.5/0.1 | 0.7/0.1 | 1.0/0.1 | 0.6/0.1 | 1.0/0.1 | 1.1/0.1 | 19.7 |
| 43L | 1.0/0.6 | 1.4/0.5 | 1.7/0.7 | 1.2/1.1 | 3.1/1.4 | 12.4/2.8 | 0.2/0.2 | 0.2/0.2 | 0.2/0.2 | 0.8/0.6 | 1.5/0.6 | 3.1/0.8 | 18.3 |
| 43R | 1.3/0.7 | 5.6/2.1 | 8.0/2.8 | 6.8/3.0 | 15.7/3.8 | 14.5/4.0 | 0.8/0.1 | 1.7/0.1 | 1.4/0.3 | 1.4/0.4 | 4.2/1.2 | 8.8/2.2 | 16.0 |
| 44L | 1.2/0.2 | 1.9/0.2 | 1.3/0.2 | 1.4/0.4 | 3.2/0.4 | 5.1/0.7 | 3.9/0.7 | 2.7/0.8 | 3.3/0.8 | 6.9/1.2 | 5.1/1.2 | 6.4/1.3 | 22.9 |
| 44R | 1.3/0.5 | 2.0/0.4 | 3.5/1.1 | 2.1/1.4 | 3.9/2.0 | 11.1/3.8 | 1.2/0.1 | 2.1/0.1 | 1.4/0.1 | 10.9/4.7 | 9.0/4.8 | 5.4/5.1 | 23.7 |
| 45L | 1.3/0.2 | 1.8/0.6 | 3.9/1.2 | 3.4/0.9 | 5.4/1.3 | 12.7/2.5 | 0.7/0.1 | 0.8/0.1 | 1.1/0.0 | 1.1/0.1 | 1.1/0.1 | 1.3/0.3 | 10.1 |
| 45R | 0.7/0.8 | 1.5/0.7 | 0.9/0.7 | 1.5/1.7 | 2.8/1.6 | 10.1/2.4 | 0.5/0.4 | 0.5/0.4 | 0.8/0.4 | 0.8/0.3 | 1.0/0.3 | 2.4/0.5 | 14.8 |
| 65L | 1.0/0.9 | 4.9/2.4 | 9.8/3.5 | 8.6/4.2 | 18.4/5.5 | 15.1/6.2 | 1.0/0.5 | 2.6/0.6 | 1.8/0.6 | 1.6/0.7 | 6.4/1.7 | 5.6/2.6 | 24.5 |
| 65R | 1.1/0.3 | 1.5/0.3 | 1.8/0.3 | 1.3/0.6 | 2.0/0.6 | 5.9/0.8 | 0.9/0.6 | 1.1/0.6 | 1.5/0.6 | 1.3/1.0 | 1.5/1.0 | 1.9/1.0 | 23.7 |
| 66R | 1.0/0.3 | 0.8/0.2 | 1.5/0.2 | 1.2/0.3 | 2.8/0.7 | 10.0/1.3 | 1.8/0.3 | 1.5/0.3 | 2.0/0.3 | 2.6/0.5 | 2.6/0.5 | 3.3/0.5 | 24.6 |
| R2 (n=6 animals) | 0.10/0.55 | 0.82/0.95 | 0.89/0.98 | 0.92/0.92 | 0.84/0.97 | 0.58/0.81 | 0.20/0.17 | 0.03/0.13 | 0.06/0.07 | 0.07/0.036 | 0.04/0.003 | 0.37/0.068 | |
| p value | 0.54/0.09 | 0.02/<0.001 | 0.01/<0.001 | 0.003/0.002 | 0.01/0.001 | 0.07/0.02 | 0.38/0.42 | 0.73/0.48 | 0.66/0.65 | 0.59/0.72 | 0.69/0.92 | 0.47/0.62 | |
| Significance | -/- | */* | */* | */* | */* | -/* | -/- | -/- | -/- | -/- | -/- | -/- | |