TABLE 5.

Study Quality Assessment Using QUADAS-2 Criteria

Reference	Risk of Bias				Applicability Concerns
	Patient Selection	Index Test	Reference Standard	Flow and Timing	Patient Selection	Index Test	Reference Standard
Dabigatran Studies
10	L	U	U	L	L	H	H
11	NA	U	U	L	H	H	H
12	NA	U	U	L	H	H	H
13	NA	U	L	L	H	L	H
14	NA	U	L	L	H	H	H
15	NA	L	L	L	H	L	H
16	NA	U	L	L	H	H	H
17	NA	U	L	L	H	L	H
18	NA	U	L	L	H	H	H
19	NA	U	L	L	H	H	H
20	NA	U	L	L	H	H	H
21	NA	U	L	L	H	L	H
22	U	U	U	L	L	H	H
23	U	U	U	L	L	H	H
24	U	U	U	L	L	H	H
25	NA	U	L	L	H	L	H
26	NA	U	L	L	H	L	H
Rivaroxaban Studies
26	NA	U	U	L	H	L	H
36	NA	U	U	L	L	L	H
37	NA	U	L	L	H	H	H
38	U	U	U	L	L	L	H
39	NA	U	L	L	H	L	H
40	NA	U	L	L	H	L	H
41	NA	U	L	L	H	L	H
42	NA	L	L	L	H	L	H
43	U	U	U	L	L	L	H
44	NA	U	L	L	H	L	H
45	NA	L	L	L	H	L	H
46	NA	L	L	L	H	L	H
47	NA	U	L	L	H	L	H
48	U	U	U	L	L	L	H
49	U	U	U	L	L	L	H
Apixaban Studies
36	L	U	U	L	L	L	H
53	L	U	U	L	H	L	H
54	NA	U	U	L	H	L	H
55	NA	L	L	L	H	L	H

H = high; L = low; U = unclear; other abbreviations as in Table 2.