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. Author manuscript; available in PMC: 2015 Aug 20.
Published in final edited form as: Neuron. 2014 Jul 31;83(4):975–988. doi: 10.1016/j.neuron.2014.07.001

FIGURE 4. FF motor neurons firing consume more than S neuron firing.

FIGURE 4

(A, B) Morphologies and firing patterns of S (A) and FF (B) motor neurons. “R” is for recording and shows where the measurements are made from.(C) Firing rate versus injected current for S (blue curve) and FF (red curve) neurons.(D) In both cell types, a reduction in [ATP]ss leads to a reduction in the amount of ATP used by the neuron (D1), but an increase in the amount of ATP needed (D2). The FF neuron both uses and needs more ATP than the S neuron and, in particular, its ATP needs are more sensitive to low levels of [ATP]ss. As [ATP]ss is reduced, both neurons depolarize and their firing rate increases (D3) with the FF neuron being more sensitive. As a consequence, the ATP needed for a single AP is higher for the FF motor neuron than for the S neuron (D4).