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. Author manuscript; available in PMC: 2015 Aug 20.
Published in final edited form as: Neuron. 2014 Jul 31;83(4):975–988. doi: 10.1016/j.neuron.2014.07.001

FIGURE 6. Spontaneous retrograde propagation of the distal depolarization towards the soma.

FIGURE 6

(A) Membrane potential along the axon. The distal axon initially generates APs locally (top panel, arrow head shows the initiation site) that move toward the soma (leftward). Over time, the initiation site moves inward along the axon (panels 2–4), with the membrane potential distal to the initiation site remaining steadily depolarized. (B) Left panel: Each curve is a profile of ΔATP at a given time, plotted against the distance to the soma. The red dots show the location of the zero values (balance between ATP needed and ATP used) along the axonal length. The right panel plots the balance point (red dots) location over time, indicating a spread of the ATP deficit from its distal origin towards the soma.