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. Author manuscript; available in PMC: 2015 Aug 20.
Published in final edited form as: Neuron. 2014 Jul 31;83(4):975–988. doi: 10.1016/j.neuron.2014.07.001

FIGURE 8. A schematic diagram of the consequence of an ATP deficit.

FIGURE 8

(A) The effects of mitochondrial ATP production acting through ATPases on the resting membrane potential and intracellular [Ca++]. VGCC indicates voltage-gated Ca++ conductances. (B) Low [ATP]ss due to mitochondrial disfunction engages a positive feedback loop that leads to increased ATP consumption and even lower [ATP]. These problems lead to pathologically high [Ca++].