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. Author manuscript; available in PMC: 2014 Sep 19.
Published in final edited form as: Brain Res. 2012 Jul 4;1471:118–128. doi: 10.1016/j.brainres.2012.06.036

Figure 4.

Figure 4

Effect of age and ischemia on phosphorylation of STAT3 in CA1 cell nuclei 3 h following reperfusion. Representative Western blots (A) and relative abundance of p-STAT3 and STAT3 (B and C) in the nuclear fraction of CA1 of placebo and estradiol (E) treated rats subjected to sham surgery or ischemia (isx). Data are expressed relative to controls (young sham) (B and C). Ischemia increased p-STAT3 in CA1 in both young and middle-aged rats (D; P < 0.01 all sham rats vs all ischemic rats). Both sham-operated and ischemic middle-aged rats had elevated p-STAT3 and total STAT3 compared to young rats (E and F; P < 0.01 all young groups vs all middle-aged groups). Estradiol increased total STAT3 in both young and middle-aged rats (G; P < 0.05 all placebo groups vs all estradiol groups). *, ** P < 0.05 and P < 0.01, respectively.