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. Author manuscript; available in PMC: 2014 Sep 19.
Published in final edited form as: Cochrane Database Syst Rev. 2011 Jan 19;(1):CD006626. doi: 10.1002/14651858.CD006626.pub2

Comparison 8. RISPERIDONE versus CLOZAPINE - sensitivity analysis (skewed data included).

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Mental state: 1. General - average endpoint score (BPRS total, high = poor) 3 368 Mean Difference (IV, Random, 95% CI) 2.84 [−1.36, 7.03]
 1.1 short term 2 316 Mean Difference (IV, Random, 95% CI) 5.19 [2.12, 8.26]
 1.2 long term 1 52 Mean Difference (IV, Random, 95% CI) −0.20 [−4.12, 3.72]
2 Mental state: 2. Positive symptoms - average endpoint score (PANSS positive, high = poor) 4 442 Mean Difference (IV, Random, 95% CI) 0.60 [−1.34, 2.53]
 2.1 short term 3 361 Mean Difference (IV, Random, 95% CI) 0.24 [−2.72, 3.19]
 2.2 medium term 1 81 Mean Difference (IV, Random, 95% CI) 0.40 [−2.78, 3.58]
3 Mental state: 3. Negative symptoms - average endpoint score (PANSS negative, high = poor) 4 442 Mean Difference (IV, Random, 95% CI) 0.14 [−2.02, 2.31]
 3.1 short term 3 361 Mean Difference (IV, Random, 95% CI) −0.39 [−3.37, 2.59]
 3.2 medium term 1 81 Mean Difference (IV, Random, 95% CI) 1.40 [−1.42, 4.22]