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Sotalol’s Papp in MDCK and MDCK-MDR1 Cells
| Apical pH | MDCK cells
|
MDCK-MDR1 cells
|
|||
|---|---|---|---|---|---|
| 7.4 | 7.0 | 6.5 | Control | W/GG918 | |
|
|
|
||||
| Papp (A→B) (× 10−6 cm/s) | 0.26 ± 0.03 | 0.21 ± 0.02 | 0.17 ± 0.02 | 0.15 ± 0.01 | 0.19 ± 0.04 |
| Papp (B→A) (× 10−6 cm/s) | 0.31 ± 0.01 | 0.33 ± 0.01 | 0.31 ± 0.03 | 1.05 ± 0.06 | 0.20 ± 0.01 |
| Efflux Ratio Papp (B→A)/Papp (A→B) | 1.2 | 1.6 | 1.8 | 7.0 | 1.1 |
