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. Author manuscript; available in PMC: 2015 Sep 24.
Published in final edited form as: Small. 2014 May 26;10(18):3729–3734. doi: 10.1002/smll.201400733

Figure 1.

Figure 1

Nanoparticle quenching of Cerenkov Luminescence. (A) CL can be produced by charged particles, for example those produced upon decay of PET-radionuclides, traveling at high speed through biological media. (B) Radionuclides at the disease site can produce detectable CL; for example [18F]-FDG uptake by tumor cells. With nanoparticle colocalization through enhanced permeability and retention or targeted nanoparticle absorbers the CL signal is quenched. This enables dual readout of disease biology with non-invasive diagnostic imaging tools that are currently in wide-spread use.