Table 4.

Outcomes and Predictors Evaluated and Summary of Results: Histologic Progression and Clinical Outcomes

Study	Outcomes Evaluated	% with Outcome	Years Follow-up (SD; range)	Predictors Significant on Multivariate Analysis	HR (95% CI)
Dienstaga 2011	1.Progression to cirrhosis	1.29%	Median 6 (NR;0.8-7)	Not performed
	2.Any clinical outcome: a) hepatic decompensation: ascites/variceal bleeding/ HE/SBP b)transplant c)HCC d)≥7 CTP score e)hepatic mortality f)overall mortality	2.31%
Everhart 2009	Combined outcome: ≥2 Increase in Ishak, hepatic mortality or hepatic decompensation (≥7 CTP score, ascites, variceal bleed, HE)	28%	Mean 3.5 (NR;NR)	Baseline Ishak (cirrhosis) HOMA2-IR (quartiles) Baseline steatosis (if cirrhosis) Mallory bodies	1.92 (1.12-3.28) 1.25 (1.08-1.45) 0.49 (0.35-0.70) 1.59 (1.10-2.31)
Fontana 2010	1.≥2 Increase in Ishak	1.34	Mean 4.25 (NR; NR)	1. Histologic progression Baseline platelet (per 50K, low) Baseline log HA	0.72 (0.57-0.91) 2.42 (0.27-4.47)
	2. Clinical Outcomes: a)Hepatic decompensation: ascites/variceal bleeding/HE/SBP b)HCC c)≥7 CTP score or d) overall mortality	2.15		2.Any clinical outcome Baseline bilirubin (elevated) Baseline INR (>1.0) Baseline albumin (low) Baseline logYKL-40	2.42 (1.42-4.13) 2.25 (1.30-3.89) 0.20 (0.10-0.38) 2.44 (1.28-4.63)
Ghany 2010	1.≥2 Increase in Ishak	1.28	Mean 3.5 (NR;NR)	1. Histologic progression Baseline BMI (high) Baseline platelets (low) Baseline steatosis	N R
	2.Clinical Outcomes: a)Hepatic decompensation: ascites/variceal bleeding/HE/SBP b) >7 CTP score or c)hepatic mortality	2.13		2.Any clinical outcome Baseline Log AST/ALT (high) Baseline bilirubin (elevated) Baseline albumin (low) Baseline platelets/ 50K (low)	3.34 (1.84-6.06) 1.82 (1.37-2.42) 0.20 (0.13-0.32) 0.59 (0.49-0.72)
Livingston 2010	1.≥1 Increase in Ishak 2.Hepatic Decompensation: ascites/esophageal varices/ HE/ coagulopathy	1.60 2.17	Mean 6.2 (NR;2.3-13.3)	Not performed

ALT= alanine aminotransferase; AST= aspartate aminotransferase; BMI= body mass index; CTP= Child-Turcotte-Pugh; CI= confidence interval; HA= hyaluronic acid; HE= hepatic encephalopathy; HCC= hepatocellular carcinoma; HCV= hepatitis C virus; HR= hazard ratio; INR= international normalized ratio; NR= not reported; RNA= ribonucleic acid; SBP= spontaneous bacterial peritonitis;

^aUnivariate significance not reported.