TABLE 4.
Growth and molecular analysis of CFU-GMs derived from uncultured CD34+/CD33− and CD34+/CD33+ progenitor cells from patients with CBF leukemias and complementing second mutation
| Sample | Mutation | CD34+/CD33− Cells | CD34+/CD33+ Cells |
|---|---|---|---|
| 1. RO50397 | t(8;21) + KIT | No mutation | CBF+ only as well as both mutations |
| 2. 792590 | t(8;21) + KIT | No mutation | CBF+ only as well as both mutations |
| 3. 71494 | t(8;21) + FLT3/ITD | CBF+ only | --- |
| 4. 600685 | t(8;21) + FLT3/ITD | CBF+ only | --- |
| 5. 715096 | t(8;21) + FLT3/ITD | CBF+ only | --- |
| 6. RO50077 | t(8;21) + FLT3/ITD | CBF+ only | CBF+ only as well as both mutations |
| 7. 719733 | t(8;21) + KIT | CBF+ only | --- |
| 8. 765326 | inv(16) + KIT | CBF+ only | --- |
| 9. 766940 | inv(16) + KIT | CBF+ only | |
| 10. 66830 | inv(16) + KIT | CBF+ only | --- |
| 11. 764821 | inv(16) + KIT | CBF+ only | CBF+ only |
| 12. 775184 | inv(16) + KIT | CBF+ only | CBF+ only as well as both mutations |
| 13. 26450 | inv(16) + NRAS | CBF+ only | CBF+ only |
| 14. 66980 | t(8;21) + KIT | CBF+ only as well as both mutations | CBF+ only as well as both mutations |
| 15. 715381 | t(8;21) + KIT | CBF+ only as well as both mutations | --- |
| 16. 750501 | t(8;21) + KIT | CBF+ only as well as both mutations | |
| 17. 58340 | t(8;21) + FLT3/ITD | CBF+ only as well as both mutations | --- |
| 18. 71863 | inv(16) + FLT3/ITD | CBF+ only as well as both mutations | No mutation |
| 19. 706269 | inv(16) + KIT | CBF+ only as well as both mutations | CBF+ only as well as both mutations |
| 20. 774353 | t(8;21) + KIT | Both mutations | CBF+ only as well as both mutations |