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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Nat Rev Genet. 2014 Jul 8;15(8):556–570. doi: 10.1038/nrg3767

Figure 4. Conceptual example of clonal evolution model and clonality analysis.

Figure 4

(A) The founding clone (yellow) persists during the course of the disease. Another clone (green) present at time point 1 faces extinction before time point 2, but new subclones (blue/time point 2 and orange/time point 3) emerge during disease progression. (B) SciClone algorithm detects the three mutation clusters present at time point 3.