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. Author manuscript; available in PMC: 2014 Sep 19.
Published in final edited form as: J Biomol Screen. 2013 Apr 15;18(8):910–920. doi: 10.1177/1087057113485789

Table 1. Structure-Activity Relationship of Skp2-Cks1 Inhibitors.

Compound Structure Inhibition of Skp2-Cks1 IC50 (μM) p27 Ub IC50 (μM)
857 graphic file with name nihms620419t1.jpg 36 ± 6.2 ~30
Q857 graphic file with name nihms620419t2.jpg 71 ± 4.4 ~15
A857 graphic file with name nihms620419t3.jpg 1090 ± 189 >300
E857 graphic file with name nihms620419t4.jpg 8311 ± 1458 >300
MHQ graphic file with name nihms620419t5.jpg 434 ± 39.5 >300
BQ graphic file with name nihms620419t6.jpg 626 ± 65.7 >300
NSC681152 graphic file with name nihms620419t7.jpg 75.6 ± 6.8 ~80

BQ, 1,4-benzoquinone; MHQ, methylhydroquinone.