Table 2.
Expression of genes causing autosomal recessive congenital ichthyosis and syndromes with ichthyosis in cultured keratinocytes
| Gene | Differentiating vs. proliferating | Differentiating | ||
|---|---|---|---|---|
| Vehicle vs. vehicle (24 h) | atRA vs. vehicle (24 h) | |||
| Fold change | Adjusted p value | Fold change | Adjusted p value | |
| ALOX12B | 5.07 | 7.14 E-17 | −2.66 | 4.69 E-10 |
| TGM1 | 4.47 | 2.67 E-21 | −0.99 | 7.45 E-07 |
| LIPN | 4.46 | 1.01 E-15 | −2.55 | 8.63 E-10 |
| PNPLA1 | 3.29 | 1.67 E-18 | −1.88 | 3.16 E-12 |
| ABCA12 | 2.89 | 5.60 E-23 | −0.01 | 0.974 |
| NIPAL4 | 2.86 | 2.20 E-17 | −0.50 | 0.004 |
| CYP4F22 | 2.81 | 4.99 E-13 | −0.69 | 0.011 |
| CERS3 | 2.00 | 1.02 E-17 | −0.33 | 0.006 |
| ALOXE3 | 1.97 | 4.66 E-14 | −1.34 | 7.60 E-10 |
| SLC27A4 | 1.16 | 9.49 E-11 | 0.04 | 0.869 |
| ABHD5 | 1.68 | 1.62 E-15 | −0.76 | 1.03 E-07 |
| ELOVL4 | 2.42 | 6.75 E-19 | −0.51 | 1.00 E-04 |
| SPINK5 | 5.24 | 2.69 E-21 | 0.33 | 0.174 |
| ALDH3A2 | 1.77 | 1.05 E-16 | −0.73 | 6.76 E-08 |
| GBA | 0.83 | 6.21 E-05 | −0.19 | 0.550 |
The effect of differentiation and exposure to all-trans retinoic acid. Genes were considered regulated if the expression levels differed more than 1.5-fold relative to controls and had an adjusted p value of <0.05