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. 2014 Sep 8;13:207. doi: 10.1186/1476-4598-13-207

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© Zhang et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Effects of Twist1 levels on CD133 expression and VM-like channel formation by breast cancer cells. MDA-MB-231 cells did not form VM-like channels when Twist1 expression was inhibited under conditions of normoxia, hypoxia, and reoxygenation, and CD133 expression was inhibited as well. When Twist1 expression was up-regulated, MCF-7 cells formed VM channels under conditions of normoxia and reoxygenation. Moreover, the tumor cells that lined the VM channels were CD133⁺. The error bar = 100 μm, and the error bar indicates the SD.