Table 1.

Brief summary of necroptosis and necrostatin-1 effects in different liver disease models

Disease model	Probable necroptosis inducer	Downstream signaling	Nec-1 effects	Ref.
Ethanol induced liver injury	TNF-α	JNK acts downstream of RIP3	No effect	[16]
Ethanol induced liver injury	TNF-α	No information	No information	[31]
APAP-induced liver toxicity	Unknown	JNK acts downstream of RIP3	Protective	[17]
APAP-induced liver toxicity	Unknown	No information	Protective	[32]
APAP-induced liver toxicity	Unknown	JNK acts downstream of RIP1	Protective	[15]
Con-A induced hepatitis model	TRAIL	PARP-1 acts downstream of RIP3	Protective	[33]
Con-A-induced hepatitis	Unknown	No information	Protective	[34]
Liver sepsis model	FasL	No information	Hepatotoxic	[25]

APAP: Acetaminophen; Con-A: Concanavalin; TNF-α: Tumor necrosis factor-α; JNK: C-Jun N-terminal kinase; RIP3: Receptor-interacting serine-threonine kinase 3; TRAIL: TNF-related apoptosis-inducing ligand; Nec: Necrostatin.