Table 3.
Cox proportional hazards model analysis of time to progression
| Variable |
Univariate |
Multivariate |
||
| HR (95%CI) | P | HR (95%CI) | P | |
| Child-Pugh grade | ||||
| A | 0.60 (0.31-1.22) | 0.1550 | ||
| B | 1.00 | |||
| Major HCC | ||||
| Intrahepatic | 1.00 | 1.00 | ||
| Extrahepatic | 0.32 (0.14-0.67) | 0.0020a | 0.36 (0.16-0.77) | 0.0070a |
| Largest tumor | ||||
| < 5 cm | 0.71 (0.36-1.52) | 0.3653 | ||
| > 5 cm | 1.00 | |||
| Hand-foot syndrome | ||||
| - | 1.00 | 1.00 | ||
| + | 0.41 (0.20-0.82) | 0.0111a | 0.44 (0.21-0.91) | 0.0274a |
| Hypertension | ||||
| - | 1.00 | 1.00 | ||
| + | 0.43 (0.21-0.84) | 0.0128a | 0.55 (0.26-1.09) | 0.0852 |
| Diarrhea | ||||
| - | 1.00 | |||
| + | 0.90 (0.54-1.40) | 0.6574 | ||
| Alopecia | ||||
| - | 1.00 | |||
| + | 0.84 (0.31-1.92) | 0.6936 | ||
CI: Confidence interval; HCC: Hepatocellular carcinoma; HR: Hazard ratio.
a
P < 0.05 vs control.