Table 1.
Univariate analysis of risk factors for combined hepatocellular-cholangiocarcinoma n (%)
| Risk factor | Cases (n = 126) | Controls (n = 504) | OR (95%CI) | P value |
| HBV | < 0.001 | |||
| HBsAg (-) | 38 (30.2) | 446 (88.5) | 1 (Reference) | |
| HBsAg (+) | 88 (69.8) | 58 (11.5) | 17.808 (11.145-28.452) | |
| HCV | 0.563 | |||
| HCV-Ab (-) | 125 (99.2) | 502 (99.6) | 1 (Reference) | |
| HCV-Ab (+) | 1 (0.8) | 2 (0.4) | 2.008 (0.181-22.322) | |
| Heavy smoking | 0.395 | |||
| No | 88 (69.8) | 371 (73.6) | 1 (Reference) | |
| Yes | 38 (30.2) | 133 (26.4) | 1.205 (0.784-1.850) | |
| Heavy alcohol consumption | 0.018 | |||
| No | 105 (83.3) | 457 (90.7) | 1 (Reference) | |
| Yes | 21 (16.7) | 47 (9.3) | 1.945 (1.115-3.392) | |
| Diabetes mellitus | 0.024 | |||
| No | 113 (89.7) | 479 (95.0) | 1 (Reference) | |
| Yes | 13 (10.3) | 25 (5.0) | 2.204 (1.094-4.443) | |
| Hypertension | 0.855 | |||
| No | 110 (87.3) | 443 (87.9) | 1 (Reference) | |
| Yes | 16 (12.7) | 61 (12.1) | 1.056 (0.586-1.903) | |
| Hepatolithiasis | 0.262 | |||
| No | 124 (98.4) | 501 (99.4) | 1 (Reference) | |
| Yes | 2 (1.6) | 3 (0.6) | 2.694 (0.445-16.294) | |
| Family history of liver cancer | < 0.001 | |||
| No | 108 (85.7) | 489 (97.0) | 1 (Reference) | |
| Yes | 18 (14.3) | 15 (3.0) | 5.433 (2.655-11.120) | |
| Family history of other malignancies | 0.636 | |||
| No | 99 (78.6) | 386 (76.6) | 1 (Reference) | |
| Yes | 27 (21.4) | 118 (23.4) | 0.892 (0.556-1.431) |
HBV: Hepatitis B virus; HCV: Hepatitis C virus; HbsAg: Hepatitis B surface antigen; HCV-Ab: Anti-HCV antibody.