Table 2.
GxE variance contribution of erythrocyte n-3 polyunsaturated fatty acids to four diabetes-related traits in GOLDN 1
| Trait | E factor | P-nominal (gxe) 2 | Vg | SE | V(gxe) | SE | h 2 (g), % (95% CI) | SE | h 2 (gxe), % (95% CI) | SE | h 2 (g + gxe), % (95% CI) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| HOMA-IR | DPA | 0.034 | 0.0007 | 0.0005 | 0.0015 | 0.0008 | 12.8 (0, 30.6) | 9.1 | 26.5 (0, 55.7) | 14.9 | 39.4 (15.9, 62.9) |
| Fasting insulin | DPA | 0.042 | 0.0002 | 0.0002 | 0.0006 | 0.0004 | 8.6 (0, 25.8) | 8.8 | 24.3 (0, 53.1) | 14.7 | 32.9 (9.87, 55.9) |
| Fasting glucose | AA/ (EPA + DHA) | 0.023 | 0.4518 | 0.3076 | 0.9295 | 0.4979 | 13.1 (0, 30.3) | 8.8 | 27.0 (0, 55.0) | 14.3 | 40.2 (17.6, 62.8) |
| Adiponectin | AA/ EPA | 0.058 | 0.0200 | 0.0044 | 0.0072 | 0.0052 | 44.4 (27.3, 61.5) | 8.7 | 16.0 (0, 38.3) | 11.4 | 60.4 (40.7, 80.1) |
1HOMA-IR, HOMA-Insulin Resistance; DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; DPA, docosapentaenoic acid; ALA, alpha -linolenic acid; AA, arachidonic acid;Vg, additive genetic variance; V(gxe), variance contributed by GxE interaction; SE, standard error; h2 (g), additive genetic heritability; h2 (gxe), heritability explained by GxE interaction; h2 (g + gxe), total heritability. GxE heritability was calculated as the GxE variance divided by the total phenotypic variance. Only the nominal significant E factors were listed in this table, results of other E factors were listed in the Additional files 1 and 2.
2 P-value (gxe) of GxE interaction was adjusted for age, sex, body mass index, study center, energy intake, kinship, and population structure.