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. Author manuscript; available in PMC: 2015 Jul 15.
Published in final edited form as: Biochem Pharmacol. 2014 May 10;90(2):166–178. doi: 10.1016/j.bcp.2014.05.001

Figure 5.

Figure 5

In vitro recombinant enzymes screening of phase I drug-metabolizing enzymes (DMEs) involved in the formation of metabolites II, III, IV, V, VI, and VII. For screening of phase I DMEs, the incubation system contained 50 mM Tris-HCl buffer solution (pH=7.4), 2 pmol CYPs or 5 mg FMOs, 2 mM MgCl2, 100 μM PZQ and 1 mM freshly prepared NADPH. The relative abundance (peak area ration of metabolites/internal standard) is given.