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. Author manuscript; available in PMC: 2015 Jul 15.
Published in final edited form as: Biochem Pharmacol. 2014 May 10;90(2):166–178. doi: 10.1016/j.bcp.2014.05.001

Table 3.

Enzymatic kinetic parameters of recombinant CYP2C9 and CYP3A4 enzymes to PZQs.

Km (μM)
CYP2C9 CYP3A4
IV V VII
(R, S)-PZQ 36.1±6.0 50.4±11.7 78.9±43.8
(R)-PZQ 25.9±4.1 N.A. 130.1±56.4a
(S)-PZQ 32.1±5.0 27.0±5.2a,* 51.9±13.9a,*
a

Values significantly different from the corresponding value of racemic PZQ (P<0.05).

*

Values significantly different from the corresponding value of the enantiomer (P<0.001).