Figure 7. Additive inhibition effect of rhEndostatin with DDP on the growth of A549 lung cancer.

Nude mice (n = 10, each) were inoculated with 6×10⁶ tumor cells subcutanously to establish the tumor-bearing model. The animals were either administered peritumorally with rhEndostatin alone at 5 mg/kg/day, 10 mg/kg/day, and 15 mg/kg/day for 15 days, successively, or combined with DDP treatment at 3 mg/kg/d every other day for 15 days. The tumor volume was measured every other day, and the formula, [(tumor volume of control-tumor volume of treatment)/tumor volume of control]×100%, was used to calculate the inhibition rate of tumor growth. #: P<0.05 vs mice administered with single rhEndostatin treatment at the same dose, respectively; *: P<0.05 vs mice treated with DDP alone at 3 mg/kg/day.