TABLE 1. Metabolites Significant for Separation of Microvesicular Steatosis Severity Scores.

Metabolite	p value	Incr/Decr	Metabolite	p value	Incr/Decr
2-Aminoadipate	<0.050	Incr	Lactate	<0.100	Decr
3-Hydroxybutyrate	<0.100	Decr	Leucine	<0.100	Decr
Acetate	<0.100	Decr	Lipoproteins	<0.100	Incr
Adenine	<0.100	Decr	O-Phosphocholine/O-acetylcholine/sn-glycerophosphocholine/carnitine	<0.005	Decr
Alanine	<0.050	Decr	Ornithine	<0.100	Decr
Ascorbate	<0.010	Decr	Phenylalanine	<0.005	Decr
Betaine/TMAO	<0.050	Decr	Serine	<0.100	Decr
Cadaverine	<0.005	Decr	Taurine	<0.100	Decr
Fumarate	<0.001	Decr	Tyrosine	<0.100	Decr
Glucose	<0.010	Decr	Unknown (0.79, 0.83 ppm)	NS	Incr
Glutamine	<0.100	Incr	Unknown (3.16 ppm)	<0.005	Incr
Glutathione	<0.100	Decr	Unknown (3.28 ppm)	<0.100	Incr
Glycylproline	<0.005	Decr	Unsaturated lipids	<0.100	Incr
Homoserine	<0.100	Incr	Valine	<0.100	Decr
Isoleucine	<0.050	Decr

Notes. Two drug-resistant strains (microvesicular steatosis severity score in INH-treated animals of 0–1; NON/ShiLtJ, C57BR/cdJ) and three drug-sensitive strains (microvesicular steatosis severity score in INH-treated animals of 2–5; NOR/LtJ, DBA/J, and LG/J) were selected for evaluation of metabolic profiling of liver tissue. All animals were binned according to low (0–1) or high (2–5) severity score and OPLS-DA analysis was performed to identify the metabolites most necessary to facilitate separation between the groups. The metabolite increase (Incr) or decrease (Decr) is listed for high microvesicular steatosis severity score animals in comparison to low microvesicular steatosis severity score animals. Significance was calculated using Student's t-test. NS: not significant at threshold of p < 0.1.