Figure 3.

Nucleotide-binding oligomerization domain 2 (NOD2) prevents Campylobacter jejuni invasion into the colon and mesenteric lymph nodes. Cohorts of 9–18 Il10^−/− and Il10^−/−; Nod2^−/− mice raised in specific-pathogen-free conditions were infected as indicated in Figure 1. A, C. jejuni (red dots) in colonic sections of infected mice was detected using fluorescence in situ hybridization. Scale bar represents 10 μm. B, C. jejuni bacterial count in the colon, mesenteric lymph nodes (MLNs), and stool of mice. Data represent means ± standard errors of the mean. *P < .05. Results are representative of 3 independent experiments. Abbreviations: CFU, colony-forming units; NS, not significant.