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. 2014 Mar 31;210(7):1100–1109. doi: 10.1093/infdis/jiu203

Figure 3.

Figure 3.

Hemoglobin type affects the intraerythrocytic multiplication factor (IMF) of clinical P. falciparum isolates. Normalized cumulative distribution function (nCDF) plots of IMF values for 2 clinical parasite isolates in normal (control) and hemoglobinopathic (α- and β-thalassemia trait) erythrocytes are shown. Lower and higher IMFs shift the curve to the left and right, respectively. Median IMFs of schizont populations correspond to nCDF values = 0.50. A, Distributions show that the parasite isolate KN1068-4 from Mali produces fewer merozoites per schizont in α-thalassemia trait erythrocytes. B, Distributions show that the parasite isolate CP803 from Cambodia produces fewer merozoites per schizont in β-thalassemia trait erythrocytes. Note that the mean IMF of CP803 is significantly lower than the mean IMFs of KN1068-4 and the P. falciparum 3D7 line. Abbreviation: thal, thalassemia.